A. Anal cancer
While HPV types 16 and 18 are thought to cause some, but not all, anal, penile, and oropharyngeal cancers, only the prevention of anal cancer is listed in the PI. It makes sense, but has not been shown in studies, that Gardasil would most likely reduce the risk of the other cancers as well.
You tell mom that the incidence of orophayyngeal cancers has been on a steady increase since the 1970s and that 80% of these cancers are in males. Mom saw on the Gardasil vaccination information sheet that about 12,000 new cases of cervical cancer are diagnosed yearly. She asks how many oropharygeal cancers are diagnosed in males and what percentage of them are caused by HPV type 16, one of the strains in the vaccine.
You tell her:
A. 800 and 88%
B. 3,500 and 74%
C. 7,200 and 61%
D. 12,300 and 74%
Answer and discussion on next page
Feel free to leave a comment first.
Markowitz LE, Dunne EF, Saraiya M, et al.; Centers for Disease Control and Prevention (CDC). Human papillomavirus vaccination: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2014 Aug 29;63(RR-05):1-30.