PHOTOCLINIC

Scarlet Fever Rash
July 28, 2011

Rarely encountered these days, scarlet fever is believed to be caused by sensitization to an erythrogenic toxin produced by strains of group A beta-hemolytic streptococci.

Cephalhematoma
July 22, 2011

A right parietal cephalhematoma was first noted on this 2-week-old girl 2 days after her birth.

Scarlet Fever
June 21, 2011

A 2-day history of fever and sore throat and an erupting rash prompted the mother of a 5-year-old boy to bring her son into the office for evaluation.

CLINICAL TRIALS

Somatropin Treatment in Patients With SHOX Deficiency and Turner Syndrome

www.clinicaltrials.gov -

Effect of Growth Hormone on Leptin, Cytokines and Body Composition of Children With Growth Failure Due to Chronic Kidney Disease

www.clinicaltrials.gov -

Phase III Randomized, Double-Blind, Placebo-Controlled Study of Acellular and Whole-Cell Pertussis Vaccines

www.clinicaltrials.gov -

NEWS

LWPES: Diet Deficits Mislabeled as Failure to Thrive

www.medpagetoday.com -

DENVER -- Children with symptoms of failure to thrive are often subjected to a battery of tests to pinpoint the problem, but, in most cases, they suffer from inadequate caloric intake, researchers fou

Medical News: ACAAI: Food Elimination for Allergies May Lead to Failure to Thrive

www.medpagetoday.com -

which the diets robbed the children of so many calories and nutrients that they developed failure to thrive. ... The first case was that of an 18-month-old boy who was admitted with diffuse rash, failure to thrive, diffuse edema, and irritability.

Comments

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20120913201856324. Personalize Your Medical News: Login Register Today. WelcomeWelcomePutting Breaking Medical News Into Practice. Please enter a search term. ADVERTISEMENT. Medpagetoday.com is optimized for viewing with javascript enabled. Please

PATIENT RESOURCES

Failure to thrive

ghr.nlm.nih.gov - 3/18/13

A service of the U.S. National Library of Medicine. Failure to thrive.

ghr.nlm.nih.gov - 3/18/13

The signs and symptoms of this condition begin in infancy and typically include vomiting, diarrhea, and an inability to grow or gain weight at the expected rate ( failure to thrive). ... Within the first weeks of life, infants develop liver disease that

Familial restrictive cardiomyopathy

ghr.nlm.nih.gov - 3/18/13

Familial restrictive cardiomyopathy can appear anytime from childhood to adulthood. The first signs and symptoms of this condition in children are failure to gain weight and grow at the expected rate ( ... failure to thrive), extreme tiredness ( fatigue),

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Failure to Thrive

Infant and Toddler With History of Cough

A 6-month-old boy has a 1-week history of dry cough that worsens at night. He has been wheezing intermittently for the past month. A 2-year-old girl has had severe nighttime cough, congestion, and fever for 2 days. She recently recovered from a respiratory illness of 1 month's duration. Chest radiographs of both patients are shown… Read More
Recommendations for Flu Vaccination

Last year, the Advisory Committee on Immunization Practices updated its vaccination recommendations to include new guidelines for children ages 6 months through 8 years, and for persons with egg allergy. Read More
Exercise and Asthma Guidelines

Patients with asthma may be reluctant to exercise for fear of triggering an attack. You can reassure them that adequate control can allow them to participate in almost any physical activity they wish. Recommendations from the NIH offer guidance on prevention of exercise-induced bronchospasm… Read More
Infant With Persistent Fever and Cough, Worsening Rash

A 14-month-old girl presented with persistent fever, cough, and worsening rash of 5 days' duration. On the first day of the illness, the infant was brought to an acute care clinic for evaluation. Read More

LATEST FEATURES

Consultant for Pediatricians. Vol. 8 No. 11

Pages: 1 2 3 4 5 6

Radiology Quiz
Hone Your Interpretive Skills

How Do You Read These Images?

By EVA ILSE RUBIO, MD—Series Editor | November 23, 2009

Dr Rubio is a pediatric radiologist at Cincinnati Children’s Hospital and assistant professor at the University of Cincinnati College of Medicine.

A 9-month-old girl was brought to the emergency department (ED) by her mother for abdominal distention, progressive failure to thrive, diarrhea, and occasional vomiting. At her 6-month well-child check-up, the infant had been at the 50th percentile in weight; now she was at the 10th percentile. She was afebrile.

Supine and decubitus views of the patient’s abdomen were ordered.

1. What do these radiographs show?
A. Small-bowel obstruction.
B. Bowel perforation.
C. Malrotation.
D. Other.

Pages: 1 2 3 4 5 6

RELATED CONTENT

How Do You Read These Images?
Consultant for Pediatricians, November 23, 2009

ACAAI: Food Elimination for Allergies May Lead to Failure to Thrive
November 12, 2006

Boy With Growth Retardation, Craniofacial Anomalies, and Hemihyperplasia
Consultant for Pediatricians, June 30, 2011

JOURNAL SCAN

Position of the American Dietetic Association: Providing nutrition services for people with developmental disabilities and special health care needs.

pubmed.gov - 2/1/10

It is the position of the American Dietetic Association that nutrition services provided by registered dietitians (RDs) and dietetic technicians, registered (DTRs), are essential components of comprehensive care for all people with developmental disabilities and special health care needs. Nutrition services should be provided throughout life in a manner that is interdisciplinary, family-centered, community-based, and culturally competent. People with developmental disabilities and special health care needs frequently have nutrition concerns, including growth alterations (failure to thrive, obesity, or growth retardation), metabolic disorders, poor feeding skills, medication-nutrient interactions, and sometimes partial or total dependence on enteral or parenteral nutrition. Individuals with special needs are also more likely to develop comorbid conditions such as obesity or endocrine disorders that require nutrition interventions. Poor health habits, limited access to services, and long

Guidelines for the diagnosis and management of chylomicron retention disease based on a review of the literature and the experience of two centers.

pubmed.gov - 1/1/10

Familial hypocholesterolemia, namely abetalipoproteinemia, hypobetalipoproteinemia and chylomicron retention disease (CRD), are rare genetic diseases that cause malnutrition, failure to thrive, growth failure and vitamin E deficiency, as well as other complications. Recently, the gene implicated in CRD was identified. The diagnosis is often delayed because symptoms are nonspecific. Treatment and follow-up remain poorly defined.The aim of this paper is to provide guidelines for the diagnosis, treatment and follow-up of children with CRD based on a literature overview and two pediatric centers 'experience.The diagnosis is based on a history of chronic diarrhea with fat malabsorption and abnormal lipid profile. Upper endoscopy and histology reveal fat-laden enterocytes whereas vitamin E deficiency is invariably present. Creatine kinase (CK) is usually elevated and hepatic steatosis is common. Genotyping identifies the Sar1b gene mutation.Treatment should be aimed at preventing potential

Guidelines for the use of infant formulas to treat cows milk protein allergy: an Australian consensus panel opinion.

pubmed.gov - 1/20/08

Three types of infant formula (soy, extensively hydrolysed and amino acid) may be appropriate for treating cows milk protein allergy. Selection of a formula depends on the allergy syndrome to be treated. Extensively hydrolysed formula is recommended as first choice for infants under 6 months of age for treating immediate cows milk allergy (non-anaphylactic), food protein-induced enterocolitis syndrome, atopic eczema, gastrointestinal symptoms and food protein-induced proctocolitis. Soy formula is recommended as first choice for infants over 6 months of age with immediate food reactions, and for those with gastrointestinal symptoms or atopic dermatitis in the absence of failure to thrive. Amino acid formula is recommended as first choice in anaphylaxis and eosinophilic oesophagitis. If treatment with the initial formula is not successful, use of an alternative formula is recommended.

What is the long term outcome for children who fail to thrive? A systematic review.

pubmed.gov - 9/1/05

To ascertain the long term outcomes in children diagnosed as having failure to thrive (FTT).|Systematic review of cohort studies. Medline, Psychinfo, Embase, Cinahl, Web of Science, Cochrane, and DARE databases were searched for potentially relevant studies. Inclusion criteria: cohort studies or randomised controlled trials in children <2 years old with failure to thrive defined as weight <10th centile or lower centile and/or weight velocity <10th centile, with growth, development, or behaviour measured at 3 years of age or older.|Thirteen studies met the inclusion criteria; eight included a comparison group, of which five included children identified in community settings. Two were randomised controlled trials. Attrition rates were 10-30%. Data from population based studies with comparison groups and which reported comparable outcomes in an appropriate form were pooled in a random effects meta-analysis. Four studies report IQ scores at follow up and the pooled standardised mean

To what extent is failure to thrive in infancy associated with poorer cognitive development? A review and meta-analysis.

pubmed.gov - 3/1/04

Previous empirical studies of the cognitive sequelae of failure to thrive in infancy have led to apparently inconsistent conclusions.|Studies of cognitive abilities in failure to thrive were located through published bibliographies, supplemented by a search through MEDLINE. They were classified (a) into those in which the cases were identified in hospital or other specialist clinics, and those in which they were identified in primary care or by whole population screening; (b) into those that were controlled and those that were not controlled; and (c) into those with a cross-sectional and those with a longitudinal design. Effect sizes in controlled studies were summarised using D statistics for the principal cognitive outcome measure, from the last occasion on which the child was tested if the study was longitudinal.|In studies with cases identified in hospital or other specialist clinics (52 cases, 36 controls), the pooled effect size (weighted standardised mean difference) for

MEDLINE

8q12.1q12.3 de novo microdeletion involving the CHD7 gene in a patient without the major features of CHARGE syndrome: case report and critical review of the literature.

pubmed.gov - 1/14/13

CHARGE syndrome is an autosomal dominant inherited disorder characterized by a specific and recognizable pattern of anomalies. De novo mutations or deletions of the gene encoding chromodomain helicase DNA binding protein 7 (CHD7) are the major cause of CHARGE syndrome. In this report, we describe a patient with a typical phenotype characterized by psychomotor retardation, hypertrichosis, facial asymmetry, synophria, failure to thrive, developmental delay and gastro-esophageal reflux, carrying a de novo 6.04Mb interstitial deletion in 8q12.1q12.3 detected by single nucleotide polymorphism (SNP) array analysis. Despite the deletion includes CHD7 and although the patient shares some of the clinical features of the CHARGE syndrome, she does not fulfill the clinical criteria for this syndrome. To the best of our knowledge, this is the second case with an entire deletion of the CHD7 gene not leading to CHARGE syndrome and, for this reason, useful to expand and further delineate the clinical

Enteral calcium infusion used successfully as treatment for a patient with hereditary vitamin D resistant rickets (HVDRR) without alopecia: a novel mutation.

pubmed.gov - 1/9/13

We report a novel mutation in a case of hereditary vitamin D resistant rickets (HVDRR) without alopecia and successful management of this condition with the intravenous formulation of calcium chloride delivered via gastric tube.|A 22 month old male (length -3.4 SDS; weight -2.1 SDS) presented with failure to thrive, short stature, severe hypocalcemia and gross motor delay. He did not have alopecia. Initial blood tests and history were thought possibly to suggest vitamin D deficiency rickets: calcium 5.1mg/dL, (8.8-10.8); phosphorus 4.1mg/dL, (4.5-5.5); alkaline phosphatase 1481 U/L (80-220); intact PTH 537.1 pg/mL (10-71). Subsequently, vitamin D studies returned that were consistent with HVDRR: 25-hydroxyvitamin D 34 ng/mL (20-100); 1,25-dihydroxyvitamin D 507 pg/mL. This diagnosis was confirmed by DNA sequencing. His subsequent clinical course was complicated by the fact that IV calcium was not a viable option for this patient, and his calcium levels could not be well controlled on

Differences in readmissions after open repair versus endovascular aneurysm repair.

pubmed.gov - 12/31/12

Reintervention rates after repair of abdominal aortic aneurysm (AAA) are higher for endovascular repair (EVAR) than for open repair, mostly due to treatment for endoleaks, whereas open surgical operations for bowel obstruction and abdominal hernias are higher after open repair. However, readmission rates after EVAR or open repair for nonoperative conditions and complications that do not require an intervention are not well documented. We sought to determine reasons for all-cause readmissions within the first year after open repair and EVAR.|Patients who underwent elective AAA repair in California during a 6-year period were identified from the Health Care and Utilization Project State Inpatient Database. All patients who had a readmission in California 1 year of their index procedure were included for evaluation. Readmission rates and primary and secondary diagnoses associated with each readmission were analyzed and recorded.|From 2003 to 2008, there were 15,736 operations for

Two cases with severe lethal course of Costello syndrome associated with HRAS p.G12C and p.G12D.

pubmed.gov - 11/1/12

Costello syndrome (CS) is a rare congenital disorder characterized by severe failure to thrive, coarse facial appearance, cardiac and skin abnormalities, developmental delay, intellectual disability, and predisposition to malignancies. Heterozygous de novo germline mutations in the proto-oncogene HRAS cause CS. About 80% of patients share the same mutation resulting in the amino acid change p.G12S and present a relatively homogeneous phenotype. Other less common lesions in HRAS can induce a milder phenotype on the one hand and a more severe phenotype on the other broadening the spectrum of clinical manifestations in CS-affected individuals. We report two new patients with the HRAS p.G12C and p.G12D substitutions and a severe neonatal manifestation causing death at the age of three months and 13 days, respectively. Both patients had particularly severe heart involvement with hypertrophic cardiomyopathy and tachyarrhythmia, generalized edema, and respiratory distress. In one case,

Clinical trial of a farnesyltransferase inhibitor in children with Hutchinson-Gilford progeria syndrome.

pubmed.gov - 10/8/12

Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare, fatal, segmental premature aging syndrome caused by a mutation in LMNA that produces the farnesylated aberrant lamin A protein, progerin. This multisystem disorder causes failure to thrive and accelerated atherosclerosis leading to early death. Farnesyltransferase inhibitors have ameliorated disease phenotypes in preclinical studies. Twenty-five patients with HGPS received the farnesyltransferase inhibitor lonafarnib for a minimum of 2 y. Primary outcome success was predefined as a 50% increase over pretherapy in estimated annual rate of weight gain, or change from pretherapy weight loss to statistically significant on-study weight gain. Nine patients experienced a 50% increase, six experienced a 50% decrease, and 10 remained stable with respect to rate of weight gain. Secondary outcomes included decreases in arterial pulse wave velocity and carotid artery echodensity and increases in skeletal rigidity and

PRACTICE GUIDELINES

National Guideline Clearinghouse | Best evidence statement (BESt). Failure to thrive treatment protocol.

www.guidelines.gov -

Best evidence statement (BESt). Failure to thrive treatment protocol.

National Guideline Clearinghouse | Best evidence statement (BESt). Parent-infant interaction and non-organic failure to thrive.

www.guidelines.gov -

Best evidence statement (BESt). Parent-infant interaction and non-organic failure to thrive.

NEWBORN_REV1

www.naspghan.org -

What is Failure to Thrive? Failure to thrive ( FTT) is a phrase that is traditionally used to describe children who have fallen short of their expected growth and development. ... How Common is FTT? About 1 of all children admitted to any hospital and 3

Celiac Guidelines.indd

www.naspghan.org -

GASTROINTESTINAL MANIFESTATIONS OF CELIAC DISEASE IN CHILDREN: Diarrhea with failure to thrive Abdominal pain Vomiting Constipation Abdominal distension Educational support for this CDHNF/NASPGHAN Clinical Practice Guideline

Microsoft Word

www.naspghan.org -

ClinicalVignettePosterSessionIIFriday, November13, 200912: 15pm 2: 15pm Esophagus/Stomach cv25ISTHEREAROLEFORUPPERENDOSCOPYINTHEEVALUATIONOFFAILURETOTHRIVE? ... Bostwick. Pediatrics,

TOPIC INDEX

• ADHD
• Allergy
• Asthma
• Atopic Dermatitis
• Autism
• Bacterial Conjunctivitis
• Developmental/Genetic Disorders
• Epilepsy
• Failure to Thrive
• Food Allergies
• GI Disorders
• Lice Treatments
• Obesity
• Respiratory Tract Diseases
• Sexually Transmitted Infections
• Skin Diseases
• Vaccines
• Vitamin D Insufficiency

PHOTO AND VIDEO FEATURES

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Multimedia
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What's Your Diagnosis?

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Finding Physician Work-Life Balance in the Small Moments
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Dos and Don’ts for Starting a Physician Blog
Michael Woo-Ming, MD, May 18, 2013
Starting a physician blog can provide your medical practice with marketing benefits, but it's important to do it right.

Failure to Thrive

Infant and Toddler With History of Cough

Recommendations for Flu Vaccination

Exercise and Asthma Guidelines

Infant With Persistent Fever and Cough, Worsening Rash

How Do You Read These Images?

Join the Conversation