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PRACTICE GUIDELINES
www.guidelines.gov -
NGC is the National Guideline Clearinghouse.
www.naspghan.org -
primary and specialist healthcare provider in the evaluation and management of gastroesophageal reflux ( GER) and gastroesophageal reflux disease ( GERD) in the pediatric age group infants, children and adolescents. ... They were written by a joint
www.nhlbi.nih.gov -
37 White, 3 not given Moderate to-severe asthma Patients presented to urban, pediatric ED Pulmonary index ( PI) score of > 8 out of 15; mean 10.2 at entry Beta2-agonist, ... Albuterol nebulized in heliox in the initial ED treatment of pediatric asthma:
www.nhlbi.nih.gov -
July 2007 2 Evidence Table 19. Managing Exacerbations: Magnesium Sulfate Study Population Citation ( Sponsor) Study Design Study N ( Number Evaluable) Population Characteristics Asthma Severity at Baseline ( if reported) Magnesium by Nebulizer
JOURNAL SCAN
pubmed.gov -
8/1/06
To evaluate the efficacy of sublingual immunotherapy (SLIT) in the treatment of allergic rhinitis in children.|A comprehensive search of the EMBASE, MEDLINE, LILACS, and CINAHL databases from January 1966 to February 10, 2006, was performed.|Randomized, double-blind, placebo-controlled trials of SLIT in the treatment of allergic rhinitis in patients 18 years or younger were selected. Outcomes measured were symptom scores and rescue medication use. Analysis was performed with standardized mean differences (SMDs) and a random-effects model.|Seventy articles were identified and reviewed. Ten studies, published between 1990 and 2004, fulfilled the selection criteria. Five hundred seventy-seven patients were initially included in the studies. Of these patients, 484 (245 SLIT and 239 placebo) had a final clinical evaluation and could be evaluated. A relevant heterogeneity due to widely differing scoring systems was found. Overall, there was a significant reduction in both symptoms (SMD, 0.56
pubmed.gov -
5/31/06
Both prenatal and postnatal passive smoking have been linked with respiratory symptoms and asthma in childhood. Their differential contributions to lung function growth in the general children's population are less clear.|To study the relative impact of pre- and postnatal exposure on respiratory functions of primary school children in a wide range of geographic settings, we analyzed flow and volume data of more than 20,000 children (aged 6-12 yr) from nine countries in Europe and North America.|Exposure information had been obtained by comparable questionnaires, and spirometry followed a protocol of the American Thoracic Society/European Respiratory Society. Linear and logistic regressions were used, controlling for individual risk factors and study area. Heterogeneity between study-specific results and mean effects were estimated using meta-analytic tools.|Smoking during pregnancy was associated with decreases in lung function parameters between -1% (FEV1) and -6% maximal expiratory
pubmed.gov -
8/17/05
Asthma mortality and morbidity continue to be a serious global problem. Systematic reviews provide an opportunity to review risk factors in detail.|To review all of the literature for risk factors associated with near-fatal asthma (NFA) and fatal asthma (FA).|A literature search from 1960 to January 2004 in MEDLINE and EMBASE was conducted. Studies were included based on the following criteria: NFA was defined as an asthma exacerbation resulting in respiratory arrest requiring mechanical ventilation or a partial pressure of CO2 of at least 45 mmHg or asthma resulting in death (FA); the study reported the number of cases (NFA and/or FA) and asthmatic controls; there was explicit reporting of risk factors; cases that were adult and pediatric in nature; and all study types. Studies that included patients with chronic obstructive pulmonary disease were excluded.|Four hundred and three articles were identified, of which 27 met the inclusion criteria. Increased use of medications such as
pubmed.gov -
7/31/05
A number of studies have investigated two common polymorphisms in the beta(2)-adrenoceptor gene, Arg/Gly16 and Gln/Glu27, in relation to asthma susceptibility. The authors performed a meta-analysis of each polymorphism, as well as haplotype analysis, for adult and pediatric populations separately, using published data, supplemented by additional data requested from the original authors. Individual analysis detected no effect of Arg/Gly16 in adults but did suggest a recessive protective effect of Gly16 for children, with an odds ratio of 0.71 (95% confidence interval (CI): 0.53, 0.96) compared with the other genotypes. Results for Gln/Glu27 in adults seem to indicate that heterozygotes are at decreased risk of asthma than either homozygote (odds ratio = 0.73, 95% CI: 0.62, 0.87), although the studies are heterogeneous; in children, the Glu/Glu genotype has a decreased risk of asthma (odds ratio = 0.60, 95% CI: 0.35, 0.99) compared with the other genotypes. Despite the proximity of
pubmed.gov -
2/14/05
Advances in the National Institutes of Health (NIH)-sponsored guidelines for asthma management result in part from how these guidelines serve as a target for improvement. Taking this perspective, we can ask what features of the guidelines are of central importance but are inadequately understood? What features are difficult to implement and would benefit from a major advance in our approach? One effort to further such advancements also comes from the NIH through their support of childhood asthma study groups that aim to improve childhood asthma management. These study groups include the Childhood Asthma Management Program, the Childhood Asthma Research and Education Network and the Inner City Asthma Consortium. The main objective of this article is to provide some insight to these NIH-supported childhood asthma study groups and their recently completed or ongoing studies. This should provide an understanding of the strengths of these initiatives, their contribution to the evidence
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