Foreign-body aspiration is a relatively common occurrence in children. It may present as a life-threatening event that necessitates prompt removal of the aspirated material. However, the diagnosis may be delayed when the history is atypical, when parents fail to appreciate the significance of symptoms, or when clinical and radiologic findings are misleading or overlooked by the physician.
Aspiration of organic matter causes severe airway mucosal inflammation. If the organic matter is not promptly removed, chronic inflammation leads to the development of granulation tissue around the foreign body, which may ultimately present as a lung infection. In this setting, it is not uncommon to treat patients for secondary complications, such as persistent fever, “asthma,” or recurrent pneumonia for long periods.
Here we review the incidence of foreign-body aspiration, its various clinical guises, its management, and measures that can prevent future aspirations.
UPPER AIRWAY OBSTRUCTION
Upper airway obstruction is one of the leading causes of pediatric emergencies. According to the National Safety Council, mechanical suffocation accounted for 5% of all unintentional deaths among children younger than 4 years in 1995 in the United States.1 Most of these deaths involved children younger than 12 months (10% of all unintentional deaths occurred in this age group).2
Pathogenesis. A foreign body in the posterior pharynx causes irritation and discomfort that causes the child to cry or cough. Vigorous inspiration causes the foreign body to become impacted within the airway;there is increased resistance to inspiratory and expiratory flow as a result. The impacted foreign body in the intrathoracic airway creates a valvelike effect that causes more airflow obstruction during expiration than during inspiration; the result is generalized or asymmetric gas trapping. Surface sensory receptors of the respiratory tract adapt to the prolonged pressure caused by the foreign body. Consequently, the child will not experience further coughing until other sensory receptors are stimulated by dislodgment of the foreign body or by secretions. Thus the patient may be asymptomatic for some time (ie, hours to months or even longer).
Epidemiology. Foreign-body aspiration accounts for more than 300 deaths annually in this country.3 Approximately 80% of episodes of foreign-body aspiration occur in those younger than 3 years.4 Most children of this age are learning to explore their world via the oral route and tend to put everything in theirmouth. The absence of the molars makes them unable to chew adequately, however. These factors increase the risk of foreign-body aspiration. Other predisposing factors include older siblings who may place food or objects in the mouth of infants or toddlers; neurologic disorders, such as cerebral palsy; loss of consciousness; and wallowing dysfunction.
During infancy, the incidence of foreign-body aspiration episodes is equal in boys and girls. After infancy, however, boys are more likely to experience aspiration than girls: the male-to-female ratio varies from 1.5:1 to 2.4:1.4,5
Food items (nuts, seeds, food particles) have been implicated in 70% to 90% cases involving infants and toddlers.6 Various types of nuts top the list of aspirated foreign bodies: peanuts are the most common (36% to 55%).5,7 Melon and sunflower seeds are also commonly aspirated.8
Older children tend to aspirate non-food items, such as paper clips, coins, balls, marbles, and pins.6 Balloon aspiration is frequently fatal.9 Balloons can pass through the vocal cords and lodge in the carina; they prevent air passage through to the lungs. As a result, balloons have been banned in many day-care centers and schools.
A foreign body may become lodged in the larynx, trachea, or bronchus. The right bronchus is more commonly affected than the left because of the lesser angle of divergence relative to the left bronchus and because of its greater diameter.7,10 Larger foreign bodies may become lodged in the larynx. Laryngotracheal foreign bodies are associated with increased morbidity and mortality.11
Signs and symptoms associated with foreign body aspiration occur in 3 phases.
Stage 1. Choking, coughing, gasping, and respiratory distress develop because of airway obstruction. Choking lasts for a few seconds to several minutes after the episode and may be self-limited.
Stage 2. Acute symptoms may be followed by a temporary quiescent phase in which the patient may not have any symptoms.
Stage 3. During the last phase, symptoms of complications such as infection may develop.
The clinical presentation depends on the child’s age, the type of object that has been aspirated, the time elapsed since the event, and the location of the foreign body. Only 50% to 75% of children present to a health facility within 24 hours of the initial aspiration.5,7 A review of 400 cases of foreign-body aspiration showed that almost 71% children presented within 1 week of aspiration.10
The most common symptoms of foreign-body aspiration are coughing, choking, and wheezing.5,7,12 Fever, stridor, chest pain, and throat or sternal discomfort occur less frequently. Laryngotracheal foreign bodies present with cough, stridor, hoarseness, and increased respiratory effort. Foreign bodies in the larynx may also manifest with symptoms related to the esophagus, such as dysphagia, gagging, or throat discomfort. Lower airway foreign bodies present as cough, wheezing, and shortness of breath; examination reveals decreased breath sounds on one side.13
Affected patients may experience little acute distress after an initial phase of choking episode. A history of choking in a previously healthy child can be elicited in 80% to 90% of patients who have aspirated a foreign body.7,12 Physical examination results may be normal or nonspecific in up to 30% patients.10 Others may have generalized or localized wheezing and decreased air entry.
Because foreign-body aspiration can mimic other respiratory conditions, a high index of suspicion is necessary in all patients with pneumonia, atelectasis, or wheezing with an atypical course—especially in patients who are unresponsive to medical therapy (see Box). This helps in the early diagnosis of foreign-body aspiration, especially in the absence of a history of choking.
Foreign-body aspiration can closely mimic an acute asthma exacerbation.14 However, the absence of atopy, the acute onset of symptoms, and unilateral physical findings may suggest foreign-body aspiration. Moreover, patients who have inhaled a foreign body fail to improve with conventional bronchodilators. Thus, clinical suspicion is crucial in the diagnostic process.
Boy With Worsening Respiratory Function: A Case History
A 6-year-old boy with well-controlled asthma presented to the emergency department (ED) with a 2-day history of fever, headache, productive cough, and dyspnea. Symptoms of asthma were not alleviated with the patient’s usual medications (budesonide and albuterol). In the ED, the patient was febrile (temperature, 40°C [104°F]). The respiratory rate was 32 breaths per minute; heart rate, 120 beats per minute. Oxygen saturation was 95% on room air.
Physical examination showed a developmentally appropriate, well-nourished child in mild respiratory distress. Auscultation of the lung fields revealed leftsided crackles and bilateral wheezing.
The patient was hospitalized with a diagnosis of pneumonia and an acute asthma exacerbation. He was treated with intravenous ceftriaxone, oral azithromycin, oral prednisolone, albuterol inhalations, and supplemental oxygen. Nevertheless, his respiratory function worsened. A chest film obtained after 24 hours of therapy showed opacification of the left lung (Figure 2).
Flexible bronchoscopy revealed a lesion that partially obstructed the left main stem bronchus. Rigid bronchoscopy confirmed the lesion to be a piece of impacted chicken meat/bone surrounded by purulent material, which could be only partly removed. There was no airway anomaly. Six additional bronchoscopies were needed before the residual material from the left lower lobe could be completely removed.
Histopathologic evaluation of the aspirate showed eosinophilic, mucoid, and fibrinopurulent material. Chest films taken after removal of the foreign body showed near complete aeration of the left lung (Figure 3).
This patient had a late presentation of symptoms probably because the aspiration was unwitnessed. The severe airway inflammatory response from the impacted chicken piece presented clinically as infectious respiratory pathology. Unfortunately, because of severe airway inflammation, repeated bronchoscopies were necessary to improve lung aeration.
Figure 1 – The chest film shows opacification of the left lung.
Figure 2 – Complete opacification of the left lung is evident after 24 hours of therapy.
Figure 3 – Near complete aeration of the left lung is apparent after the foreign body was removed.
1. Rovin JD, Rodgers BM. Pediatric foreign body aspiration. Pediatr Rev. 2000;21:86-90.
2. Schmidt H, Manegold BC. Foreign body aspiration in children. Surg Endosc. 2000;14:644-648.
3. Black RE, Johnson DG, Matiak ME. Bronchoscopic removal of foreign bodies in children. J Pediatr Surg. 1994;29:682-684.
4. Rothmann BF, Boeckman CR. Foreign bodies in the larynx and tracheobronchial tree in children. A review of 225 cases. Ann Otol Rhinol Laryngol. 1980;89:434-436.
5. Burton EM, Brick WG, Hall JD, et al. Tracheobronchial foreign body aspiration in children. South Med J. 1996;89:195-198.
6. Darrow DH, Holinger LD. Aerodigestive tract foreign bodies in the older child and adolescent. Ann Otol Rhinol Laryngol. 1996;105:267-271.
7. Tan HK, Brown K, McGill T, et al. Airway foreign bodies (FB): a 10-year review. Int J Pediatr Otolaryngol 2000;56:91-99.
8. Pasaoglu I, Dogan R, Demircin M, et al. Bronchoscopic removal of foreign bodies in children: retrospective analysis of 822 cases. Thorac Cardiovasc Surg. 1991;39:95-98.
9. Rimell FL, Thome A Jr, Stool S, et al. Characteristics of objects that cause choking in children. JAMA. 1995;274:1763-1766.
10. Mu L, He P, Sun D. Inhalation of foreign bodies in Chinese children: a review of 400 cases. Laryngoscope. 1991;101:657-660.
11. Lima JA. Laryngeal foreign bodies in children: a persistent, life-threatening problem. Laryngoscope. 1989;99:415-420.
12. Even L, Heno N, Talmon Y, et al. Diagnostic evaluation of foreign body aspiration in children: a prospective study. J Pediatr Surg. 2005;40:1122-1127.
13. Lima AB, Fischer GB. Foreign body aspiration in children. Paed Resp Rev. 2002;3:303-307.
14. De Bilderling G, Mathot M, Bodart E. Asthma in the young child: when should inhaled foreign body be suspected? Rev Med Liege. 2001;56:759-763.
15. Tokar B, Ozkan R, Ilhan H. Tracheobronchial foreign bodies in children: importance of accurate history and plain chest radiography in delayed presentation. Clin Radiol. 2004;59:609-615.
16. Narasimhan KL, Chowdhary SK, Suri S, et al. Foreign body airway obstructions in children: lessons learnt from a prospective audit. J Indian Assoc Pediatr Surg. 2002;7:184-189.
17. Reilly J, Thompson J, MacArthur C, et al. Pediatric aerodigestive foreign body injuries are complications related to timeliness of diagnosis. Laryngoscope. 1997;107:17-20.
18. Cataneo AJ, Reibscheid SM, Ruiz Junior RL, Ferrari GF. Foreign body in the tracheobronchial tree. Clin Pediatr. 1997;36:701-706.
19. Silva AB, Muntz HR, Clary R. Utility of conventional radiography in the diagnosis and management of pediatric airway foreign bodies. Ann Otol
Rhinol Laryngol. 1998;107:834-838.
20. Svedstrom E, Puhakka H, Kero P. How accurate is chest radiography in the diagnosis of tracheobronchial foreign bodies in children? Pediatr Radiol. 1989;19:520-522.
21. Mu LC, Sun DQ, He P. Radiological diagnosis of aspirated foreign bodies in children: review of 343 cases. J Laryngol Otol. 1990;104:778-782.
22. Appelgate KE, Dardinger JT, Leiber ML, et al. Spiral CT scanning technique in the detection of aspiration of LEGO foreign bodies. Pediatr Radiol. 201;31:836-840.
23. American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care: Pediatric Basic Life Support. Circulation. 2005;112:156-166.
24. Banerjee A, Rao KS, Khanna SK, et al. Laryngo-tracheo-bronchial foreign bodies in children. J Laryngol Otol. 1988;102:1029-1032.
25. Martinot A, Closset M, Marquette CH, et al. Indications for flexible versus rigid bronchoscopy in children with suspected foreign-body aspiration.
Am J Respir Crit Care Med. 1997;155:1676-1679.
26. Ciftci AO, Bingol-Kologlu M, Senocak ME, et al. Bronchoscopy for evaluation of foreign body aspiration in children. J Pediatr Surg. 2003;38:1170-1176.
27. Steen KH, Zimmermann T. Tracheobronchial aspiration of foreign bodies in children: a study of 94 cases. Laryngoscope. 1990;100:525-530.
28. American Academy of Pediatrics. Guidelines for Health Supervision III. 3rd ed. Elk Grove Village, Ill: American Academy of Pediatrics; 1997:91.
29. Mechanical airway obstruction: choking, strangulation, and suffocation. In: Widome MD, ed. Injury Prevention and Control for Children and Youth. Elk Grove Village, Ill: American Academy of Pediatrics. 1997:285.